Fiber Optic Systems
Fiber Optic Systems:
The automation of dissolution testing almost became a necessity in the 1970s, with the onset of regulatory requirements insisting on a performance check for solid dosage forms. Intensive manual labor, long turnaround times from run to run, analyst-to-analyst variability in sampling and filtering and current 21 CFR Part 11 requirements have all been driving the dissolution world's movement toward some sort of automated technique.The use of fiber optics allows the direct measurement of dissolved drug in the dissolution vessel via an individual probe for each dosage unit tested. The system essentially "pumps" light from a spectrophotometer to the vessel and the carry the light back to the spectrophotometer where absorbance is measured. No tubes are required to carry sample solutions from one place to another. No filters are necessary to filter the samples.